Research and innovation



To achieve our goal of excellence and be an innovative competitor in our markets,  we are constantly striving to improve the services we offer to our customers.  By listening to their requirements and technological advances, we can develop tools and services adapted to meet the challenges of tomorrow.

The culture of innovation within Staphyt promotes the continuous improvement of our employees’ working comfort, performance,  productivity and responsiveness.



Each year Staphyt invests 10% of its turn-over to maintain a high level of performance in all services. Our experts are involved in national and international working groups and so actively take part to both methodology and regulation reflection and evolution.

In partnership with public and academic institutes, we innovate in setting up new evaluation methods for plant protection and nutrition products.


11 August 2022

Thanks to our geographical coverage in Europe, we give you access to a large range…

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Thanks to our geographical coverage in Europe, we give you access to a large range of crops in EPPO North, Central and South Europe for testing your conventional and biological products.

Some examples of studies we work on in autumn season :

  • Efficacy testing for all types of products (GEP)
  • Ability to use inoculum and irrigation to optimize pressure
  • Biopesticides and biostimulants studies
  • Abiotic stress test (water stress, saline stress…)
  • Fertilisation studies by controlled drip, foliar application, Sowing,….
  • Seed treatment trials
  • Herbicides (screening with specific weed sowing…)
  • Fungicides (Decision Support Tools (DST) use, preventive application in summer against Sclerotinia, ….)
  • Insecticides (cabbage stem flea beetle, Phyllotreta…)
  • Mollucids (field and laboratory box studies)






Spain | New satellites trials sites now available across Spain completing our 3 stations based in Filiel, Sevilla and Valencia: Galicia, Extremadura, Lleida & Zaragoza, Malaga & Granada.

Italy | Opening of a 4th Phytosanitary trial station in Sicily giving access to mediterranean crops (Vineyard, Citrus fruits, Arboriculture, Market-garden).

Greece | 2 new ginning machines acquired to manage GLP cotton trials (separation of seed and fiber), one for Greece and one in Spain.

Germany | Recruitment of Jörg Euler, PPP & PNP Business Development Manager.
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Bulgaria | New station in Pyrwenec in the South, newly GEP accredited that comes in addition to Plovdiv(South) and Dobritch in the North east, both as well GEP accredited.

Poland | GEP audits has been done with success and a new GEP certificate extending our research permission for bio-stimulants and bio-preparations has been obtained.

Ukraine | Despite the situation in Ukraine, our team managed all requested spring trials and is securing the work for autumn in Kaharlyk or Pervomaisk stations.

Morocco | Great season of GEP trials in our 3 locations, Meknés, Agadir & Marrakech, and a good start of GLP trials.

France | New building and new capacity for the phytopathology and plant nutrition Laboratory in Martillac, Renovation of the Dame Marie les Bois Station (37095).
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Elicitors are products known to activate plant defense pathways thereby limiting pathogen infection. In the context of crop protection, the development of elicitors is a promising strategy to reduce the use of conventional products.

To be approved as an elicitor in the European Union, a product must be shown to stimulate the plant immune system at a molecular level, protect plants against pathogen and not have antimicrobial properties.

Staphyt has developed various tools to evaluate the efficacy of elicitors, from the screening of molecules to their registration.

First, the efficacy of new molecules in activating plant defenses can be assessed using a qualitative method based gene reporter system (GUS) to monitor the regulation of expression of markers genes that reflect salicylic acid or jasmonic defense pathway activation. This test allows to simply observe the expression of these genes by the appearance of a blue coloration and easily identify candidates able of activating plant defenses.

Thereafter, the efficiency of the products in activating the plant defense, can be quantified by measuring by RT-qPCR, the expression of marker genes specially selected to be the most relevant to reflect the plant defense status. Moreover, absence of direct biocide effect towards pathogens can be tested in vitro in order to confirm that products ‘efficacy is due exclusively to an elicitation of plant defense mechanisms. Finally, efficacy of the product against many pathogens can be evaluated on potted plants in controlled conditions and in field trials.
Learn more about Staphyt’s laboratory at Martillac, Bordeaux, France.

For field trials, several agronomic parameters could have an impact on elicitor efficacy. Therefore, it is essential to confirm the activation of plant defense after elicitor treatment in order to link efficacy against pathogens to elicitor efficacy.

Staphyt is developing an easy way to sample leafs in field by using FTA cards. We developed a method to extract the RNA pool from the cards and measure, by RTqPCR, the level of expression of defense marker genes.

Our tests confirmed that the expression pattern of defenses genes is comparable between samples from FTA cards and samples frozen in liquid nitrogen for arabidopsis and tomato.

This methodology should be a promising strategy to evaluate in field trials the elicitors’ efficacy and would be extended to other plant species.





As expected, Regulation (EU) 2019/1009 has entered into force on July, 16th 2022, repealing at the same time Regulation (EC) 2003/2003 that covered only mineral fertilizers. This new regulation extends the possibility of registration at European scale to organic fertilizers and biostimulants. Sales can be done after self certification (Module A) for the simplest fertilizers or by evaluation by a notified body of the compliance check dossier (Modules B+C or Module D1).

Beware, however, that for products under self certification rule, the labelling requirements as well as the content of the technical documentation to keep available in case of controle have changed compared to requirements of Regulation 2003/2003 and this applies for all batches produced from July 16th. Components registration conditions under Reach have also evolved.

Contact us for any support required in terms of regulatory positioning, validation of requirements or preparation of technical documentation.

Référence Agro – Gaëlle GaudinApril 28, 2022 Risk assessment, Biocontrol solutions

Staphyt, which has been supporting crop protection companies for more than thirty years in the development and marketing of active substances and products, reviews for Référence agro the changes observed in recent years. The tightening of conventional products evaluations and the rise of biosolutions are at the heart of his work. Meeting with Amélie Grimaldi and Geoffroy Moulin, respectively in charge of regulatory affairs and coordinator of biological expertise for the company.

For thirty years, Staphyt has been involved in the development of plant protection products, risk assessment, and the preparation of registration dossiers for substances and products to be marketed throughout Europe. Staphyt has been able to observe the gradual evolution towards less chemical plant protection specialities and the evolution of dedicated regulations.

Rise of startups since 2017

“We work with a large number of players in the industry, from preliminary laboratory screening work to the marketing of the plant protection product,” says Geoffroy Moulin, biosolutions coordinator for the company. The first biocontrol product we dealt with was in 2006. But since 2017, we have seen the rise of startups in biosolutions and for the past three years, the massive arrival of conventional industrials on these alternative solutions. The sponsors of the latest editions of ABIM, the annual meetings of the biocontrol industry, are proof of this. These agrochemists are developing their product portfolio through partnerships with these startups. And vice versa: a large number of startups approach these large companies every year.”

Amélie Grimaldi, head of regulatory affairs, is supported by toxicologists, ecotoxicologists, environmental experts, chemists, residue specialists and agronomists. The division has a total of 70 employees out of Staphyt’s 240 in France. Obtaining the regulatory data required for the approval of a substance or the marketing authorization of a speciality requires all these skills,” explains the manager. But startups do not have a regulatory department, or not as complete. As for large companies, they call on us when they have to deal with peaks in workload.

Because putting together a regulatory dossier is time consuming. “We count more than a thousand hours of work to re-evaluate a single product in the three European Union zones, following the renewal of an active substance,” says Amélie Grimaldi.

The renewal of an active substance requires more work than in the past because of the increased requirements.

Reduction of the chemical load of the products

The number of conventional active substances approved at European level is falling, but chemistry is still dominant. At Staphyt, many dossiers concern reformulated conventional products. “We often have to reduce the authorized doses compared to what was accepted ten years ago,” notes Geoffroy Moulin.

Ten years ago, Staphyt set up a team of agronomists, scientists and regulatory experts to study biosolutions. Because biosolutions are on the rise and require a distinct technical and regulatory approach.

Over the past three years, the number of low-risk substances approved at the European level has doubled, the number of micro-organisms has also almost doubled and the number of natural substances has tripled.

“The share of biocontrol in our turnover has doubled in the last four years,” Geoffroy Moulin reports.

Biopesticides boosted by numerous advantages

Biopesticides are growing rapidly because of the advantages they represent,” adds Amélie Grimaldi. The cost of a dossier is lower, particularly because the number of studies is lower, as the substance is automatically eliminated if it presents a risk, apart from its irritant nature. For the approval of a biological active substance, it is necessary to count 2 M€, against sometimes 10 M€ for a conventional substance. Development and evaluation times are also shortened and approval periods are lengthened. Finally, these alternative specialties benefit from political support, both at the European and national levels.

Proving the effectiveness of a biopesticide is difficult

However, the regulatory manager is keen to temper these advantages. It’s not always easy to put together dossiers because the requirements, guidance documents and risk assessment are not all well adapted to these specialties,” she says. In addition, national regulations differ, which makes registration in Europe more complex. It is also more difficult to accurately characterize the substance of a biopesticide and prove its efficacy. Finally, while the cost of risk assessment is lower for these specialties, the cost to find the optimal positioning, as well as the cost of marketing support, are more substantial.

Conventional agrochemists work on solutions that combine conventional and biosolutions. “The trial programs for such combined solutions are gaining momentum,” says Amélie Grimaldi.

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